Indications:
Disinfect and antisepticise wounds due to trauma or surgery, deep ulcers.
Clean and wash medical equipment before sterilization.
Administration, dosage:
Administration: Apply the undiluted solution to the skin to disinfect or to the damaged area to avoid infection. If necessary, cover the wound with bandage.
Dosage: Apply POVIDONE to the wound once to twice per day.
Some special attention on the handling of the medicine before and after use:
There are no special requirements for handling this medicine after use.
Contraindications:
Hypersensitivity to iodine. Children under 2 years of age, particularly infants.
Frequently use in patients with thyroid disorders (particularly the colloid goiter, endemic goiter and Hashimoto’s thyroiditis). Pregnancy and lactation.
Perforated eardrum or direct application to the meninges. Severe injured cavity. Not to be taken internally.
Warnings and precautions for use:
Caution should be considered when using regularly on wounds in people with a history of renal failure, in patients receiving lithium treatment.
Pregnancy and lactation:
Avoid frequent use for pregnant and lactating women because iodine crosses the placental barrier and excretes in milk. Although there is no evidence of harm, caution should be considered and the therapeutic benefit should be weighed against the possible effects of iodine absorption on the development and fetal thyroid function.
Effects on ability to drive and use machines:
Povidone iodine has no known influence on the ability to drive and use machines.
Interactions, incompatibilities of medicine:
Interactions:
Antibacterial effect is reduced in the presence of alkalis and proteins.
Effect of POVIDONE is not lost by soap. Interaction with mercury compounds may cause causticity.
This drug is inactivated by sodium thiosulfate, sunlight, high temperature and other disinfectants.
This drug may interfere with thyroid function tests.
Incompatibilities:
Because there are no studies about the incompatibility of the medicine, it should not be mixed with other medicines.
Undesirable effects:
Side effects are classified according to frequency: Very common (ADR ≥ 1/10), common (1/100 ≤ ADR < 1/10), uncommon (1/1,000 ≤ ADR < 1/100), rare (1/10,000 ≤ ADR < 1/1,000), very rare (ADR < 1/10,000); cannot be estimated from the available data “Not known”.
POVIDONE may cause metabolic acidosis, hypernatremia and impaired renal function in extensive wounds and severe burns.
POVIDONE may cause hypothyroidism and if there is potential hypothyroidism, it may cause a session of thyrotoxicosis.
Neutropenia (in patients with severe burns).
Inform your physician about undesirable effects encountered when using POVIDONE.
Overdose and management:
Overdose: Excessive iodine may cause goiter, hypothyroidism or hyperthyroidism. Using this medicine repeatedly on extensive damaged or burned skin may cause many undesirable effects such as metallic taste, increased salivation, mouth and throat sores; eye irritation, swelling, stomachache, diarrhea, difficulty breathing due to pulmonary edema. Metabolic acidosis, hypernatremia and impaired renal function may occur.
Management: In case of accidental ingestion of large quantities of povidone-iodine, symptomatic and supportive treatment is recommended, with special attention to electrolyte balance, renal and thyroid function.
Pharmacodynamics:
Pharmacotherapeutic group: Antiseptics and disinfectants.
ATC code: D08AG02.
Povidone iodine when applied to the mucosa will release free iodine with strong antiseptic properties due to oxidizing properties. In addition, it has a fungicidal effect, so it is used to treat some skin diseases.
Pharmacokinetics:
Topical solution with direct effects on bacteria, fungal cells and excreted on the mucosal surface.
Storage conditions, shelf life, quality specification of the medicine:
Storage conditions: Protect from humidity and light, below 300C.
Shelf life: 24 months from the manufacture date. Do not use the drug after the expiry date printed on the label.
Quality specification: In house.
