|Dosage and administration:||
Follow the doctor’s instructions:
Patients with hypersensitivity to piracetam or any of excipient of this drug.
|Warnings and precautions for use:||
Piracetam is excreted by the kidney, so the increase in half-life is directly related to the decrease in renal function and creatinine clearance. Special care must be taken when treating patients known to suffer from renal insufficiency. Monitoring of renal function is recommended in such cases and in elderly patients. (Dosage adjustment is based on creatinine clearance)
|Recommendation for pregnant women and breastfeeding mothers:||
Piracetam should not be administered to pregnant women and breastfeeding mothers.
|Effects on ability to drive and use machines:||
Piracetam almost does not affect the ability to drive and operate machinery. However, the risk of dizziness has been also reported, therefore depending on specific case the doctor may recommend the patients whether to drive or use machinery or not.
|Interactions, incompatibilities of medicine:||
– Conventional treatment may still be applied to treat alcoholism (vitamins and sedatives) in case of patients suffering from vitamin deficiency or strong agitation.
|Undesirable effects (ADR):||
Common, ADR > 1/100
|Overdose and treatment:||
Piracetam is non-toxic even in high doses. Special measures are not required in case of accidental overdose.
Piracetam (a cyclic derivative of gamma-aminobutyric acid (GABA) acts directly on the brain to improve the efficacy of the telencephalon (this area of the brain is involved in cognition and also has a role to play in learning and memory, in alertness and in consciousness). Piracetam acts on a number of neurotransmitters such as acetylcholine, noradrenaline, dopamine etc. This may explain the positive effects of piracetam on learning and improving the ability to perform memory test. It can alter neurotransmission within the brain, and can help to improve the metabolic environment essential for good neuronal function.
Piracetam is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability is approximately 100%. Peak plasma levels (40 – 60 micrograms/ml) are reached within 30 minutes after oral dose of 2 g. Peak cerebrospinal fluid concentrations are achieved 2-8 hours after oral administration. Long term use of piracetam does not change the absorption. The volume of distribution is approximately 0.6 L/kg.
|Storage conditions, shelf-life, quality specification of the medicine:||
Storage conditions: Store the medicine below 30 degree C. Protect from humidity and light.
Composition: Each film-coated tablet contains:<br/>
Piracetam. . . . . . . . . . . . . . . . . . . . . . 800 mg<br/>
Box of 10 blisters x 10 film-coated tablets.<br/>
For the symptomatic treatment of vertigo.<br/>
Treatment of memory impairment, dizziness, poor concentration or lack of alertness, mood changes, behavioral disorders, personal negligence, dementia produced by multiple infarcts in elderly patients.<br/>
Treatment of acute ischaemic stroke. It is noted that age and initial severity of stroke are the most important factors to predict the potential survival after acute ischaemic stroke.<br/>
Treatment of alcoholism.<br/>
Treatment of sickle-cell anemia.<br/>
Piracetam is used as an adjunct in the treatment of myoclonus of cortical origin.