|Dosage and administration||
Hypersensitivity to aciclovir, or any of the excipients.
|Warnings and precautions for use||
Adequate hydration should be maintained, especially in patients receiving high doses of aciclovir. Caution should be taken when administering aciclovir to following subjects:
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
There have been no studies to investigate the effect of aciclovir on driving performance or the ability to operate machinery.
|Interactions, incompatibilities of medicine||
Probenecid: Increases plasma half-life and AUC of aciclovir, reduces urinary excretion and renal clearance of aciclovir.
|Undesirable effects (ADRs)||
After oral administration of aciclovir undesirable effects have been observed:
|Overdose and management||
Symptoms: Precipitation of aciclovir in renal tubules, which may occur when the solubility 2.5 mg/mL or serum creatinine is increased; renal impairment; agitation; restlessness; tremors; seizures; palpitations, high blood pressure, difficulty urinating.
Aciclovir is a nucleoside analogue (acycloguanosine) with selective effect on Herpes virus-infected cells. Aciclovir is phosphorylated after entry into herpes infected cells to the active compound aciclovir triphosphate. At the first step of this process aciclovir is converted by viral thymidine kinase to aciclovir monophosphate which is further converted into aciclovir diphosphate and triphosphate by a number of other cellular enzymes. Aciclovir triphosphate inhibits viral DNA synthesis and replication without affecting the normal cellular processes.
The bioavailability of oral aciclovir is approximately 20% (15-30%). Food does not affect the absorption. Aciclovir is widely distributed to body fluids and tissues such as the brain, kidneys, lungs, intestines, liver, spleen, muscle, uterus, vaginal mucosa and vaginal secretions, tears, aqueous humor, amniotic fluid, semen, cerebrospinal fluid.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each tablet contains:<br/>
Aciclovir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 800 mg<br/>
Presentation: Box of 2 blisters x 10 tablets.<br/>
Treatment of Varicella zoster virus infection (chickenpox) and Herpes zoster virus (shingles) (excluding neonatal HSV and severe HSV infections in immunocompromised children).<br/>
Agiclovir 800 is recommended for use only in children over 6 years of age.