|Dosage and administration||
Hypersensitive to bromhexine or to other ingredients of this medicine.
|Warnings and precautions for use||
Bromhexine should be avoided in combination with antitussives, drugs that reduce bronchial secretions because they may cause a risk of stagnant phlegm in the respiratory tract.
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
No studies on the effects on ability to drive and use machines have been performed.
|Interactions, incompatibilities of medicine||
Bromhexine should not be used in combination with mucolytics (including drugs that reduce bronchial secretions) such as atropine-like drugs (or anticholinergics) due to reduction of the bromhexine effect.
|Undesirable effects (ADRs)||
Uncommon, 1/1000 < ADR < 1/100
|Overdose and management||
Bromhexine hydrochloride is a mucolytic agent. It activates sialomucin synthesis and disrupts mucopolysaccharide acid fibers; so, it makes the sputum thinner and less viscid. Bromhexine facilitates bronchial sputum ejection effectively.
Bromhexine is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver so its bioavailability is about 20%. Food increases the bioavailability of bromhexine hydrochloride. Peak plasma concentrations are reached after ½ hour to 1 hour.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each hard capsule contains:
Bromhexine hydrochloride . . . . . . . . . . . . . .4 mg
3 blisters of 10 hard capsules in a carton box.
10 blisters of 10 hard capsules in a carton box.
HD bottle containing 200 hard capsules.
For the treatment of bronchial secretion disorders, particularly in acute bronchitis, acute exacerbations of chronic bronchitis.
Bromhexine is often used as an adjunct to antibiotics for the treatment of severe respiratory infections.