|Dosage and administration||
– Hypersensitivity to meloxicam or to any of the excipients, a history of hypersensitivity to aspirin or other nonsteroidal anti-inflammatory drugs.
|Warnings and precautions for use||
Meloxicam should be carefully indicated to patients with a history of gastric and duodenal ulcers, or patients concomitantly taking anticoagulants because meloxicam can cause gastric and duodenal ulcers or hemorrhage.
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
Meloxicam has no influence on the ability to drive and use machine. However, vertigo, drowsiness may occur in some cases. If affected, patients should be advised not to drive or operate machinery.
|Interactions, incompatibilities of medicine||
Meloxicam has an increased synergistic effect on the inhibition of cyclo-oxygenase with other nonsteroidal anti-inflammatory drugs at high doses, this may increase the risk of gastrointestinal ulcers and bleeding. The concomitant use of meloxicam with other NSAIDs is not recommended.
|Undesirable effects (ADRs)||
Like other nonsteroidal anti-inflammatory drugs, meloxicam may cause unwanted effects in many organs of the body especially the gastrointestinal tract, blood, kidneys and skin. Attention should be paid to the risk of cardiovascular thrombotic events (see Warning and precautions).
|Overdose and management||
There is no specific antidote of meloxicam. Patients should be managed with symptomatic and supportive care following meloxicam overdose. Measures used to accelerate the removal and reduce the absorption of meloxicam should also be useful, such as gastric lavage, oral cholestyramine.
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID), a derivative of oxicam, with anti-inflammatory, analgesic and antipyretic properties. As with other NSAIDs, meloxicam inhibits the synthesis of prostaglandins, which are mediators playing an important role in pathogenic mechanisms of inflammation, fever, pain process.
– Absorption: Meloxicam is well absorbed from the gastrointestinal tract, which is reflected by a high absolute bioavailability of 89% following oral administration compared to intravenous injection, food has negligible influence on the absorption.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each tablet contains:
Meloxicam. . . . . . . . . . . . . . . . . . . . . . . . 15 mg
Box of 3 blisters x 10 tablets.
Agimesi 15 tablets are used for treatment of osteoarthritis, ankylosing spondylitis and other chronic joint diseases.