|Dosage and administration||
Patients with hypersensitivity to lisinopril or to other angiotensin converting enzyme (ACE) inhibitors or to any excipient of the drug.
|Warnings and precautions for use||
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
Lisinopril has no known influence on the ability to drive and use machines. However, patients who drive and use machines should use lisinopril with caution because it may occasionally cause headache, fatigue.
|Interactions, incompatibilities of medicine||
|Undesirable effects (ADRs)||
The following undesirable effects have been observed and reported during treatment with Lisinopril tablets and other ACE inhibitors with the following frequencies:
|Overdose and management||
Symptom of overdose can be hypotension.
Lisinopril, the lysine analogue of enalapril, is a long-acting angiotensin converting enzyme (ACE) inhibitor. Angiotensin converting enzyme is an endogenous enzyme which plays a role in the conversion of angiotensin I to angiotensin II. Angiotensin I increases in certain diseases such as heart failure and kidney disease, caused by increased response to renin. Angiotensin II has effects on stimulating growth in cardiac myocytes, leading to enlarged heart (hypertrophic cardiomyopathy), and on vasoconstriction, causing hypertension. ACE inhibitors reduce angiotensin II and aldosterone levels, thereby reduce sodium and water retention, dilate peripheral blood vessels, reduce peripheral resistance in both systemic and pulmonary circulation. In addition, lisinopril also affects the kallikrein – kinin system, reduces the degradation of bradykinin, leading to increased level of bradykinin, which is the cause of some unwanted effects such as angioedema and persistent cough due to ACE inhibitors.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each tablet contains:
Lisinopril. . . . . . . . . . . . . . . . . . . . . . . . . 20 mg
Blister of 10 tablets, box of 3 blisters.
Treatment of hypertension: Lisinopril is used alone or in combination with other antihypertensives such as thiazide diuretics, alpha blockers or calcium channel blockers.
Treatment of heart failure: Lisinopril is used in combination with cardiac glycosides and diuretics for the treatment of congestive heart failure in patients who are not responding adequately to diuretics and digitalis.
Acute myocardial infarction in hemodynamically stable patients: Short-term (6 weeks) treatment lisinopril is combined with thrombolytics, aspirin and/or beta blockers to improve survival of hemodynamically stable patients with acute myocardial infarction. Lisinopril is used within 24 hours of the onset of acute myocardial infarction.
Treatment of renal disease in hypertensive patients with type 2 diabetes mellitus and incipient nephropathy.