|Dosage and administration||
A known hypersensitivity to dexamethasone or to any of the excipients of this product.
|Warnings and precautions for use||
In patients with bacterial infections or suspected infections, special attention should be exercised and specific antibiotic therapy is primarily required. Because of immunosuppressive effects of dexamethasone that may result in exacerbation of intercurrent and widespread infections.
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
Dexamethasone has no influence on ability to drive and use machines.
|Interactions, incompatibilities of medicine||
Avoid co-administration of dexamethasone with following drugs: Everolimus, natalizumab, nilotinib, nisoldipine, ranolazine, tolvaptan, vaccines (live).
|Undesirable effects (ADRs)||
Common, ADR > 1/100
|Overdose and management||
Symptoms: Reports of acute toxicity and/or deaths following overdosage with glucocorticoids are rare, symptoms commonly seen are anaphylactic shock or hypersensitivity.
Dexamethasone is fluomethylprednisolone, a synthetic glucocorticoid, which is virtually insoluble in water. Glucocorticoids acts by binding to intracellular glucocorticoid receptor, translocating to the cell nucleus, and thereby affecting some transcribed genes. Glucocorticoids also have some direct effects, which may not be mediated via binding to the receptor. Dexamethasone has the main effects of glucocorticoid that are anti-inflammatory, anti-allergic, and immunosuppressive properties. Dexamethasone has little effect on electrolyte balance. Comparing the strength for the anti-inflammatory effect, dexamethasone is about 30 and 7 times stronger than hydrocortisone and prednisolone, respectively.
In general, corticosteroids are well absorbed from the gastrointestinal tract, which are then distributed to all body tissues. They cross the placenta and may be excreted in small amounts in breast milk.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each tablet contains:
Dexamethasone acetate . . . . . . . . . . . . . . . .0.554 mg
(Equivalent to Dexamethasone . . . . . . . . . . . 5 mg)
Cardboard box containing 10 blisters of 10 tablets.
Box of 1 HD bottle containing 200 tablets.
HD bottle contains 500 tablets.
Steroid non-specific therapy, when active treatment is required, such as treatment of asthma, severe allergic reactions, blood transfusion reactions, laryngitis.
Combination with other therapies for the treatment of cerebral edema, or shock due to various causes.
Prophylactic steroid in surgery where reservoir of glucocorticoids is considered insufficient except for primary adrenocortical insufficiency (Addison’s disease).
Dexamethasone is used to test and diagnose Cushing’s syndrome.
Dexamethasone has been used to differentiate Cushing’s disease (adrenal hyperplasia caused by defects of pituitary origin) from other forms of Cushing’s syndrome (caused by ectopic ACTH secretion from non-pituitary tumours or by cortisol secretion from adrenal tumours).
Dexamethasone is widely used to prevent chemotherapy-induced nausea and vomiting.