|Dosage and administration||
Dosage: Dosage should be individualized on the basis of both response and tolerance.
Hypersensitivity to glimepiride or to any of the excipients, or to other sulfonylureas, or to sulfonamide derivatives.
|Warnings and precautions for use||
Glimepiride must be taken immediately before or during meals.
|Recommendation for pregnancy and breastfeeding||
|Effects on ability to drive and use machines||
There is no information about the effects of glimepiride on ability to drive or use machine. However, caution should be exercised when using the drug for the driver or the operator because their ability to concentrate and their response may be reduced due to high or low blood glucose levels and visual impairment. Patients should be advised to take precautions to avoid hypoglycaemia whilst driving.
|Interactions, incompatibilities of medicine||
Concurrent administration of glimepiride with other drugs may result in increased or decreased effects of glimepiride. Therefore, patient should consult the treating doctor before taking another medicine.
|Undesirable effects (ADRs)||
The most important ADR is hypoglycemia.
|Overdose and management||
Glimepiride is a sulphonylurea agent used in the treatment of non-insulin-dependent (type II) diabetes mellitus. Glimepiride acts mainly by stimulating beta-cells of the pancreatic islets of Langerhans to release insulin, thus, it works only if the pancreas remains active (beta cells still produce insulin).
The bioavailability of glimepiride is very high. Food intake does not alter significantly the absorption, only the absorption rate is slightly slower. Maximum plasma concentrations are reached approximately 2.5 hours after oral administration.
|Storage conditions, shelf-life, quality specification of the medicine||
Storage conditions: Protect from humidity and light, below 30 degrees C.
Composition: Each tablet contains:
Glimepiride. . . . . . . . . . . . . . . . . . . . . . . . 4 mg
Cardboard box containing 3 blisters of 10 tablets.
Glimepiride is indicated for the treatment of type II diabetes mellitus in adults, when diet, physical exercise and weight reduction alone are not adequate.